|
| Study | Sample size (T/C) | Disease course (1∼3 m/4∼6 m/>6m) | Olfactory function (N/P) | Age year (mean ± SD) | Gender
male/female | Control | Intervention | Main treated acupoints and treatment frequency | Course (weeks) | Adverse events (T/C) |
|
| Pang et al. 2016 [32] | 30/30 | T: 30 (14/5/11);
C: 30 (19/5/6) | T: 13/17
C: 16/14 | T: 50.2 ± 14.3
C: 47.1 ± 12.1 | T: 8/22
C: 6/24 | No treatment | Acupoint injection | Acupoint injection: Yingxiang (LI20). 3 times a week for 3 months. 10 times is 1 course with a treatment interval of 3∼5 days | 3 m | Treatment success rate (UPSIT) |
| Pang et al. 2016 [32] | 25/30 | T: 25 (10/5/10);
C: 30 (19/5/6) | T: 10/15
C: 16/14 | T: 54.2 ± 12.7
C: 47.1 ± 12.1 | T: 11/14
C: 6/24 | No treatment | Acupoint injection | Acupuncture:Yingxiang (LI20), Shangyingxiang (EX-HN8), BiQiu. 3 times a week for 3 months | 3 m | Treatment success rate (UPSIT) |
| Ma and Feng 2020 [33] | 45/45 | T: 7–18 (11.7 ± 2.4) m;
C: 5–17 (11.5 ± 2.1) m | T: 19/26
C: 17/28 | T: 41.1 ± 3.6
C: 40.8 ± 3.2 | T: 24/21
C: 25/20 | Olfactory training + drug therapy | Acupuncture + Acupoint injection + C | Acupuncture: Yingxiang (LI20), Shangyingxiang (EX-HN8), Yintang (EX-HN3). 3 times a week for 3 months.
Acupoint injection: Yingxiang (LI20). 3 times a week for 3 months. 10 times is 1 course with a treatment interval of 3∼5 days | 3 m | Effective rate (T&T);
QOD-P |
| Wang et al. 2020 [34] | 30/30 | T: 30 (9/10/11);
C: 30 (11/9/10) | T: 12/18
C: 14/16 | T: 49.7 ± 2.2
C: 49.3 ± 2.3 | T: 14/16
C: 10/20 | Drug therapy | Acupoint injection + C | Acupoint injection: Tiantu (RN22). 2 times a week for 3 months.8 times is 1 course | 3 m | Effective rate (ΔVAS) |
| Wang 2020 [34] | 30/30 | T: 30 (10/7/13);
C: 30 (11/9/10) | T: 14/16
C: 14/16 | T: 49.8 ± 2.5
C: 49.3 ± 2.3 | T: 9/21
C: 10/20 | Drug therapy | Acupoint injection + C | Acupoint injection: Yingxiang (LI20). 2 times a week for 3 months. 8 times is 1 course | 3 m | Effective rate (ΔVAS) |
| Zhang 2018 [35] | 33/29 | T: 7–22 (12.9 ± 5.6) m;
C: 6.5–21 (13.8 ± 4.5) m | T: 17/16
C: 15/14 | T: 40.5 ± 8.3
C: 41.3 ± 8.9 | T: 12/21
C: 10/19 | Olfactory training + drug therapy | Acupuncture + C | Acupuncture: Yingxiang (LI20), Shangyingxiang (EX-HN8), Cuanzhu (BL2). 3 times a week for 3 months | 3 m | Effective rate (T&T) |
| Wilkinson 2010 [36] | 15/15 | 4.3 y | None | T: 63.1 ± 6.8
C: 61.43 ± 8.72 | T: 8/7
C: 8/7 | Vitamin B complex (B1, B6, B12) oral 12 weeks | Acupuncture | Acupuncture: Fengfu (LG16), Baihui (LG20), Yingxiang (LI20), Lieque (LU7), Taiyuan (LU9), ZusanLi (ST36), TaiXi (KD3). 2 times a week for 10 weeks | 10 w | Sniffin’s Sticks TDI score |
| Dai et al. 2016 [37] | 25/25 | T: 25 (10/5/10);
C: 25 (15/5/6) | T: 10/15
C: 11/14 | T: 54.2 ± 12.7
C: 49.1 ± 12.8 | T: 11/14
C: 5/20 | No treatment | Acupuncture | Acupuncture: Yingxiang (LI20), Shangyingxiang (EX-HN8), BiQiu. 3 times a week for 3 months. 10 times is 1 course with a treatment interval of 3∼5 days | 3 m | Treatment success rate (UPSIT);
UPSIT score |
|
