The Aqueous Extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum Mixture Protects Striatal Neurons and Movement-Associated Functionalities in a Rat Model of Diabetes-Induced Locomotion Dysfunction

Figure 4

Effects of fructose/STZ-induced type 2 diabetes on spontaneous locomotion (a) and effects of the aqueous extract of the SNP mixture on spontaneous locomotion in T2D rats (b). Data are shown as mean ± SEM, 20 ≤ n ≥ 5 in (a) and n = 5 in (b);  < 0.01 and  < 0.001: significant as compared to normal control; ^# < 0.05 and ^## < 0.01: significant as compared to diabetic control; Met 200: diabetic animals receiving metformin at 200 mg/kg b.w.; SNP 150, 300: diabetic animals receiving the aqueous extract of the mixture at 150 and 300 mg/kg b.w.

(a)

(b)