Absorption and Metabolism of Urolithin A and Ellagic Acid in Mice and Their Cytotoxicity in Human Colorectal Cancer Cells

Figure 2

HPLC analysis of mice urine samples of vehicle control (1.6% DMSO and 6.25% Tween-20 in 160 µL water, black line) and urolithin A (0.6 mg/mouse, orange line) group. The urines were collected at indicated time points (0, 3, 6, 9, 12, and 24 h) after gavage feeding of urolithin A. The retention time (RT) of urolithin A and urolithin B is 7.6 min and 15.5 min, respectively.