Electroacupuncture Alleviates Pain Responses and Inflammation in Collagen-Induced Arthritis Rats via Suppressing the TLR2/4-MyD88-NF-κB Signaling Pathway

Figure 7

OxPAPC intervention relieved the inflammation and joint pain in CIA rats. (a) Measurement of the hind paw edema once a week from day 0 to day 42. Measurement of the hind paw (b) mechanical withdrawal threshold and (c) thermal withdrawal latency once a week from day 0 to day 42. (d) The contents of TNF-α, IL-1β, and IL-6 in serum. (e) Histopathological analysis of ankle joints. Scale bar: 200 μm. (f) The expression levels of NF-κB p-p65 in ankle synovium. (Data were expressed as mean ± SD, n = 8 per group in Figure (a–d), n = 4 per group in Figure (e and f), , compared with the CIA + vehicle group).

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