Safety Evaluation of the Polyherbal Formulation NawaTab: Acute and Subacute Oral Toxicity Studies in Rats

Figure 3

Light micrographs of liver tissues showing the classic hepatic lobule including the middle of the central vein (CV), hepatocytes arranged in radiating cords from the central vein, and sinusoidal spaces between the cords. Normal hepatic morphology was found in all experimental groups. (a) Control, (b) 250, (c) 500, and (d) 1000 mg/kg BW of NawaTab. Light micrographs of liver tissue showing the portal area and its structures, including the interlobular branches of the bile duct (green arrowhead), hepatic artery (red arrowhead), and portal vein (V) surrounded by hepatocytes. There were no differences in portal structures between any of the experimental groups. (e) Control, (f) 250, (g) 500, and (h) 1000 mg/kg BW of NawaTab.