Safety Evaluation of the Polyherbal Formulation NawaTab: Acute and Subacute Oral Toxicity Studies in Rats

Table 2

Clinical biochemistry parameters of NawaTab-treated rats in the subacute toxicity study.

Parameters	Control	NawaTab (mg/kg BW)
		250	500	1000
Males
ALP (U/L)	140.8 ± 12.1	152.4 ± 11.3	121.0 ± 7.0	123.8 ± 8.9
ALT (U/L)	33.8 ± 2.5	31.6 ± 2.2	27.6 ± 1.4	28.2 ± 1.8
AST (U/L)	128.6 ± 14.1	134.8 ± 7.5	112.6 ± 14.9	124.4 ± 14.9
T-bil (mg/dL)	<0.15	<0.15	<0.15	<0.15
D-bil (mg/dL)	<0.09	<0.09	<0.09	<0.09
TP (g/dL)	5.62 ± 0.02	5.56 ± 0.06	5.68 ± 0.04	5.67 ± 0.09
Glo (g/dL)	1.45 ± 0.08	1.38 ± 0.04	1.56 ± 0.08	1.50 ± 0.08
Alb (g/dL)	4.17 ± 0.07	4.18 ± 0.05	4.12 ± 0.05	4.17 ± 0.06
BUN (mg/dL)	20.4 ± 1.5	19.4 ± 0.7	20.0 ± 0.5	19.2 ± 0.9
Cre (mg/dL)	0.22 ± 0.01	0.23 ± 0.02	0.22 ± 0.01	0.22 ± 0.01
TG (mg/dL)	136.2 ± 19.3	70.6 ± 14.2	101.4 ± 26.2	90.0 ± 22.2
TC (mg/dL)	66.2 ± 5.7	75.4 ± 1.1	74.6 ± 5.7	63.2 ± 2.6
Females
ALP (U/L)	81.0 ± 2.5	80.2 ± 4.8	70.0 ± 5.5	68.8 ± 8.6
ALT (U/L)	29.2 ± 1.9	25.2 ± 1.1	24.8 ± 1.6	28.8 ± 1.4
AST (U/L)	127.5 ± 10.1	130.2 ± 24.0	130.0 ± 9.4	121.0 ± 8.8
T-bil (mg/dL)	<0.15	<0.15	<0.15	<0.15
D-bil (mg/dL)	<0.09	<0.09	<0.09	<0.09
TP (g/dL)	5.62 ± 0.02	6.27 ± 0.12	6.23 ± 0.19	6.60 ± 0.08
Glo (g/dL)	1.25 ± 0.03	1.47 ± 0.07	1.34 ± 0.10	1.57 ± 0.03
Alb (g/dL)	4.17 ± 0.07	4.80 ± 0.05	4.89 ± 0.16	5.03 ± 0.07
BUN (mg/dL)	20.4 ± 1.5	17.4 ± 0.6	16.2 ± 0.4	15.5 ± 0.5
Cre (mg/dL)	0.22 ± 0.01	0.28 ± 0.01	0.25 ± 0.01	0.22 ± 0.01
TG (mg/dL)	57.2 ± 10.2	77.4 ± 20.5	63.2 ± 7.8	86.5 ± 6.8
TC (mg/dL)	45.5 ± 1.7	46.4 ± 2.8	47.0 ± 5.8	64.8 ± 5.8

Data are expressed as the mean ± S.E.M., n = 5 animals/sex/group. , significantly different from control group.