Research Article
Safety Evaluation of the Polyherbal Formulation NawaTab: Acute and Subacute Oral Toxicity Studies in Rats
Table 3
Hematological parameters of NawaTab-treated rats in the subacute toxicity study.
| | Parameters | Control | NawaTab (mg/kg BW) | | 250 | 500 | 1000 |
| | Males | | WBC (×103 cells/μL) | 4.02 ± 0.33 | 5.48 ± 0.52 | 5.04 ± 0.66 | 5.05 ± 0.56 | | NE (%) | 5.64 ± 3.79 | 3.62 ± 1.57 | 3.37 ± 1.23 | 1.45 ± 0.09 | | LY (%) | 82.44 ± 4.20 | 86.26 ± 1.83 | 85.03 ± 3.71 | 85.98 ± 1.20 | | MO (%) | 10.42 ± 1.26 | 8.82 ± 0.64 | 10.77 ± 2.68 | 11.25 ± 1.23 | | EO (%) | 1.08 ± 0.20 | 1.02 ± 0.15 | 0.57 ± 0.09 | 1.00 ± 0.30 | | BA (%) | 0.42 ± 0.12 | 0.28 ± 0.02 | 0.27 ± 0.03 | 0.32 ± 0.05 | | RBC (×106 cells/μL) | 7.89 ± 0.28 | 7.67 ± 0.11 | 7.92 ± 0.12 | 7.97 ± 0.18 | | HGB (g/dL) | 14.76 ± 0.23 | 14.90 ± 0.32 | 14.83 ± 0.50 | 14.90 ± 0.31 | | HCT (%) | 47.16 ± 1.42 | 47.04 ± 0.67 | 48.10 ± 1.79 | 47.82 ± 0.80 | | PLT (×103 cells/μL) | 785.0 ± 69.4 | 789.0 ± 29.6 | 715.0 ± 47.5 | 680.0 ± 52.1 | | MCV (fL) | 59.80 ± 0.89 | 61.30 ± 0.59 | 60.70 ± 1.95 | 60.10 ± 0.95 | | MCH (pg) | 18.80 ± 0.48 | 19.40 ± 0.21 | 18.70 ± 0.59 | 18.70 ± 0.33 | | MCHC (g/dL) | 31.34 ± 0.58 | 31.68 ± 0.28 | 30.87 ± 0.26 | 31.15 ± 0.30 | | RDW (%) | 12.30 ± 1.08 | 12.02 ± 0.69 | 12.20 ± 0.15 | 11.15 ± 0.12 |
| | Females | | WBC (×103 cells/μL) | 2.28 ± 0.53 | 2.61 ± 0.34 | 3.36 ± 0.51 | 3.51 ± 0.31 | | NE (%) | 10.74 ± 3.51 | 9.20 ± 4.80 | 4.88 ± 2.14 | 2.70 ± 0.23 | | LY (%) | 76.18 ± 4.55 | 76.70 ± 3.80 | 82.22 ± 2.48 | 85.85 ± 1.27 | | MO (%) | 10.06 ± 1.13 | 12.50 ± 1.98 | 11.56 ± 0.36 | 10.35 ± 1.21 | | EO (%) | 1.04 ± 0.25 | 1.15 ± 0.18 | 0.58 ± 0.08 | 0.52 ± 0.13 | | BA (%) | 1.98 ± 0.94 | 0.45 ± 0.12 | 0.76 ± 0.24 | 0.58 ± 0.05 | | RBC (×106 cells/μL) | 8.07 ± 0.12 | 7.52 ± 0.10 | 7.97 ± 0.17 | 7.99 ± 0.11 | | HGB (g/dL) | 15.66 ± 0.27 | 14.52 ± 0.49 | 15.40 ± 0.32 | 15.72 ± 0.37 | | HCT (%) | 46.86 ± 0.89 | 44.72 ± 1.08 | 46.84 ± 1.30 | 48.58 ± 0.74 | | PLT (×103 cells/μL) | 596.0 ± 74.8 | 619.5 ± 78.2 | 720.6 ± 72.8 | 759.8 ± 31.1 | | MCV (fL) | 58.10 ± 0.92 | 59.50 ± 0.73 | 58.70 ± 0.53 | 60.90 ± 1.20 | | MCH (pg) | 19.40 ± 0.36 | 19.30 ± 0.49 | 19.30 ± 0.24 | 19.70 ± 0.44 | | MCHC (g/dL) | 33.46 ± 0.58 | 32.48 ± 0.82 | 32.92 ± 0.47 | 32.38 ± 0.42 | | RDW (%) | 11.16 ± 0.39 | 10.9 ± 0.64 | 11.28 ± 0.71 | 10.93 ± 0.28 |
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Data are expressed as mean ± S.E.M, n = 5 animals/sex/group.
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