Hispidin Inhibits Ferroptosis Induced by High Glucose via the miR-15b-5p/GLS2 Axis in Pancreatic Beta Cells

Figure 1

HG treatment caused ferroptosis in PBCs. (a) PBCs treated with glucose (25 mM, HG; 5 mM, ctrl) for 24 h; cell viability was measured. (b) PBCs treated as indicated for 24 h; cell death was measured. (c) PBCs treated with HG alone or with various inhibitors for 24 h; cell viability was measured. (d) PBCs treated with HG alone or with various inhibitors for 24 h; cell death was measured. (e)–(h) PBCs treated with HG alone or with different ferroptosis inhibitors for 24 h. PBCs cultured under normal conditions were used as the control. (e) ROS levels measured. (f) Fe²⁺ levels measured. (g) MDA levels measured. (h) GSH levels measured. Data are representative of at least three independent experiments (; ).

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