Antiplatelet and Antithrombotic Activities of <i>Lespedeza cuneata</i> via Pharmacological Inhibition of Integrin <i>α</i>IIb<i>β</i>3, MAPK, and PI3K/AKT Pathways and FeCl3-Induced Murine Thrombosis

<div>Inhibitory mechanism of <i>L. cuneata</i> on the platelet signaling pathway. <i>L. cuneata</i> inhibits the phosphorylation of MAPKs (ERK, JNK, and p38MAPK) and PI3K/Akt, limiting the release of granules and reducing platelet aggregation. In addition, by affecting calcium mobilization, granule secretion, and platelet aggregation, MAPK and PI3K/Akt, and downstream effectors of SFK, play crucial roles in platelet activation inhibition.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 10

Figure 10: Antiplatelet and Antithrombotic Activities of <i>Lespedeza cuneata</i> via Pharmacological Inhibition of Integrin <i>α</i>IIb<i>β</i>3, MAPK, and PI3K/AKT Pathways and FeCl3-Induced Murine Thrombosis 

Figure 10 | Antiplatelet and Antithrombotic Activities of Lespedeza cuneata via Pharmacological Inhibition of Integrin αIIbβ3, MAPK, and PI3K/AKT Pathways and FeCl3-Induced Murine Thrombosis 