Research Article
Homotherapy for Heteropathy: A Molecular Mechanism of Poria Sini Decoction for Treatment of Liver Cancer and Chronic Heart Failure
Table 2
Experimental verification results of main chemical constituents.
| Active ingredient | Disease | Treatment mechanism | Experiment model | Literature |
| Naringenin | LC | Naringenin induces growth inhibition, cell cycle arrest, and apoptosis in human hepatocellular carcinoma cells | Cell culture | [23] |
| Naringenin | CHF | Naringenin attenuates pressure overload-induced cardiac hypertrophy | Mice | [24] |
| Isorhamnetin | LC | Isorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells | Cell experiment | [25] |
| Isorhamnetin | CHF | Isorhamnetin exerts a protective effect against myocardial injury through the attenuation of apoptosis | Cell culture | [26] | Living organisms |
| Calycosin | LC | Calycosin has a potential effect in inhibiting oncogene expression and increasing anticancer genes expression | Cell culture | [27] |
| Calycosin | CHF | Calycosin inhibited inflammation and fibrosis via activation of the PI3K-AKT pathway in postacute myocardial infarction rats | The rat | [28] |
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Note. LC: liver cancer; CHF: chronic heart failure.
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