Multimodal Exercise in Older Patients with Advanced Pancreatic Cancer Undergoing First-Line Chemotherapy: A Case Series Examining Feasibility and Preliminary Efficacy
Table 2
Changes in patient-reported outcomes.
Measures
Case #1
Case #2
Case #3
Case #4
Case #6
T0
T1
%
T0
T1
%
T0
T1
%
T0
T1
%
T0
T1
%
BSI-18
Depression, aT-score
42.0
42.0
0.0
42.0
42.0
0.0
50.0
50.0
0.0
48.0
48.0
0.0
57.0
48.0
−15.8
Anxiety, aT-score
39.0
39.0
0.0
39.0
39.0
0.0
39.0
39.0
0.0
60.0
60.0
0.0
48.0
48.0
0.0
Somatisation, aT-score
47.0
47.0
0.0
58.0
58.0
0.0
66.0
66.0
0.0
58.0
58.0
0.0
62.0
57.0
−8.1
Global severity index, aT-score
41.0
41.0
0.0
50.0
50.0
0.0
57.0
57.0
0.0
57.0
57.0
0.0
58.0
53.0
−8.6
EORTC QLQ-C30
Global health status/QoL, score (0–100)
66.7
83.3
25.0
25.0
83.3
233.3
41.7
58.3
40.0
50.0
83.3
66.7
66.7
58.3
−12.5
Functional scales, score (0–100)
Physical functioning
93.3
100
7.1
60.0
93.3
55.6
66.7
80.0
20.0
80.0
100.0
25.0
80.0
60.0
−25.0
Role functioning
100
100
0.0
16.7
83.3
400.0
16.7
66.7
300.0
66.7
83.3
25.0
100
33.3
−66.7
Emotional functioning
100
100
0.0
100
100
0.0
91.7
100.0
9.1
91.7
91.7
0.0
50.0
58.3
16.7
Cognitive functioning
100
100
0.0
100
100
0.0
100.0
100.0
0.0
100
100
0.0
83.3
66.7
−20.0
Social functioning
66.7
100
50.0
33.3
100
200.0
50.0
66.7
33.3
50.0
66.7
33.3
100.0
100.0
0.0
Symptoms scales/items, score (0–100)
Fatiguea
33.3
22.2
−33.3
55.6
11.1
−80.0
66.7
33.3
−50.0
33.3
11.1
−66.7
33.3
77.8
133.3
Nausea and vomitinga
0
0
0.0
16.7
0
−100.0
33.3
16.7
−50.0
33.3
33.3
0.0
0
0
0.0
Paina
0
0
0.0
0
0
0.0
0
33.3
200.0b
0
0
0.0
16.7
0
−100.0
Dyspnoeaa
33.3
0
−100.0
33.3
0
−100.0
33.3
33.0
0.0
0
0
0.0
33.3
66.7
100.0
Insomniaa
33.3
0
−100.0
66.7
33.3
−50.0
33.3
0
−100.0
66.7
33.3
−50.0
33.3
33.3
0.0
Appetite lossa
33.3
33.3
0.0
66.7
0
−100.0
0
0
0.0
0
0
0.0
33.3
66.7
100.0
Constipationa
33.3
0
−100.0
0
0
0.0
0
0
0.0
33.3
0
−100.0
33.3
33.3
0.0
Diarrheaa
0
0
0.0
0
33.3
100.0c
100
0
−100.0
0
0
0.0
0
0
0.0
Financial difficultiesa
33.3
0
−100.0
0
0
0.0
0
0
0.0
0
0
0.0
0
66.7
200.0c
FACIT-F, total score (0–52)
46.0
49.0
6.5
23.0
47.0
104.4
19.0
36.0
89.5
43.0
49.0
14.0
45.0
27.0
−40.0
BSI-18, Brief Symptom Inventory-18; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core Module; FACIT-F, Functional Assessment of Chronic Illness Therapy-Fatigue; T0, baseline; T1, postintervention; %, percentage change. aNegative change represents an improvement. bCalculated after adding the smallest possible value greater than 0 for the pain scale (i.e., 16.7) to both baseline and posttest values. cCalculated after adding the smallest possible value greater than 0 for the diarrhoea/financial difficulties item (i.e., 33.3) to both baseline and posttest values. Bold type indicates clinically important improvements.
