Translating Evidence from Dutch Exercise Oncology Trials in Patients with Breast Cancer into Clinical Practice Using the RE-AIM Framework

Table 1

Definitions of the RE-AIM framework and operationalization used in the current study.

Reach	Refers to the number and characteristics of participants when compared to the target audience
	Operationalization: reach was evaluated by the number and characteristics of participants included in the exercise trials when compared to the target population
Effectiveness	Refers to the positive and negative consequences of the intervention under optimal conditions or real-world circumstances, respectively
	Operationalization: effectiveness was evaluated by the impact of an intervention on aerobic fitness, fatigue, quality of life, self-reported physical function, and patient satisfaction
Adoption	Refers to the staff and settings that participate
	Operationalization: adoption was evaluated as the representativeness of settings and satisfaction of staff involved in the Dutch exercise trials
Implementation	Refers to the extent to which the program was implemented as intended, i.e., intervention fidelity and resources (e.g., cost and time)
	Operationalization: implementation was evaluated by (i) the participants’ adherence to an exercise program and (ii) resources and intervention costs
Maintenance	Refers to the long-term effects, both at the level of the individual patient and at the level of the organization in terms of the sustainability of the program delivery over time in the settings without added resources and leadership
	Operationalization: we describe maintenance at both the patient (individual) and setting level. At the patient level, maintenance has been defined as the long-term effects (≥6 months) of the intervention. At the setting level, we examined the extent to which the exercise programs are institutionalized or part of the routine organizational practices and policies