|
| | No. | Study arms | Mean age (SD) | Timing of the intervention and duration | Description of the intervention (FITT)a |
|
| PACT–breast cancer [17, 18] | 204 | Intervention (n = 102)
Control (usual care) (n = 102) | Intervention: 49.7 (8.2)
Control: 49.5 (7.9) | During chemotherapy and/or radiotherapy
Duration = 18 weeks | F: 2x/week
I: (i) AE: HR at or below VT
(ii) RE: 65% of 1RM (2 × 10) towards 45% of 1RM (2 × 20)
T: 60 min
T: (i) AE: interval training of alternating intensity (25 min)
(ii) RE: major muscle groups (25 min) |
|
| PACES-breast cancer [23, 24] | 230 | OnTrack (n = 76) supervised exercise program
Onco-move (n = 77) home-based, individualized, self-managed PA program
Control (usual care) (n = 77) | OnTrack: 49.8 (8.4)
Onco-move: 50.5 (10.1)
Usual care: 51.6 (8.8) | During chemotherapy
Duration = start in week of first chemotherapy cycle until 3 weeks after the last cycle of chemotherapy (mean = 118.6 days of length of chemotherapy) | OnTrack
F: 2x/week
I: (i) AE: 50–80% of Wmax as estimated by SRT
(ii) RE: 70% of 1RM (2 × 12) towards 80% of 1 RM (2 × 8)
T: 60 min
T: (i) AE: min. Duration of 10 min per exercise (total 30 min)
(ii) RE: ≥6 exercises of major muscle groups (20 min)
Onco-move
F: 1x/3 weeks + 2 weeks after start (per telephone)
I: moderate intensity–Borg 12–14
T: 30 min per day
T: activities depend on patient preference |
|
| UMBRELLA Fit [31, 32] | 260 (TwiCs design; n = 68 accepted the intervention) | Intervention (n = 130)
Control (usual care) (n = 130) | Intervention: 58.0 (9.8)
Control: 58.3 (9.5) | After cancer treatment (except for hormonal therapy)
Duration = 12 weeks | F: 2x/week
I: (i) AE: week 1–3: 40-6-%% HRR + HRrest week 4–8: 60–70% HRR + HRrest; week 9–12 : 60–75% HRR + HRrest + interval-training
(ii) RE: week 1–3: 1 × 20–25rep (20RM) 9 exercises week 4–12: 2 × 15–20 rep (15RM) 7 exercises
T: 60 min
T: (i) AE: gradually increase, week 1–3: 15–20 min week 4–8: 15–20 min MI & 5–10 min HI week 9–12 : 10 min moderate intensity & 10 min HIIT, 10 × 30 sec, 1 min active rest
(ii) RE: major muscle groups |
|
| REACT [27, 28] | 181
Breast | HI (n = 62)
LMI (n = 62)
WLC (n = 57) | HI: 51.7 (9.5)
LMI: 51.8 (10.5)
WLC: 51.9 (8.2) | After chemotherapy
Duration = 12 weeks | HI
F: 2x/week
I: (i)AE: first 4 weeks 2 × 8 min with alternating workloads
(ii) (30/65% MSEC) after 4 weeks 1 × 8 min interval
(iii) Supplemented with 3 × 5 min constant workload
(iv) (≥80% HRR)
(v) RE: 70% 1RM (2 × 10) to 85% 1RM (2 × 10)
T: 60 min
T: (i) AE: two types of endurance interval exercises
(ii) (week 1–4: 16 min week ≥ week 5 : 25 min)
(iii) RE: 6 exercises of major muscle groups (25 min)
LMI:
F: 2x/week
I: (i) AE: first 4 weeks 2 × 8 min with alternating workloads
(ii) (40/55% MSEC) after 4 weeks 1 × 8 min interval
(iii) supplemented with 3 × 5 min constant workload
(iv) (40–50% HRR)
(v) RE: 40% 1RM (2 × 10) to 55% 1RM (2 × 10)
T: 60 min
T: (i)AE: two types of endurance interval exercises
(ii) (week 1–4: 16 min week ≥ week 5 : 25 min)
(iii) RE: 6 exercises of major muscle groups (25 min) |
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