Susceptibility of Developing Renal and Lung Cancer in Polycystic Kidney Disease Patients: An Evidence in Reaching Consensus

Table 3

SIR for cancers stratified by age and PKD duration.

Site of cancers	Total			Male			Female
	Obs.	Exp.	SIR (95% CI)	Obs.	Exp.	SIR (95% CI)	Obs.	Exp.	SIR (95% CI)
By age
Age < 65 years
All cancers	31	21.28	1.46 (0.99–2.07)	20	12.6	1.59 (0.97–2.45)	11	8.68	1.27 (0.63–2.27)
Lung & mediastinum	5	1.73	2.89 (0.93–6.74)	2	1.13	1.78 (0.20–6.41)	3	0.61	4.96 (1.00–14.48)
Kidney	4	0.54	7.39 (1.99–18.93)	2	0.34	5.93 (0.67–21.41)	2	0.2	9.81 (1.10–35.41)
Age ≧ 65 years
All cancers	51	47.25	1.08 (0.80–1.42)	39	33.96	1.15 (0.82–1.57)	12	13.3	0.90 (0.47–1.58)
Lung & mediastinum	10	6.86	1.46 (0.70–2.68)	7	5.35	1.31 (0.52–2.70)	3	1.51	1.98 (0.40–5.79)
Kidney	4	1.61	2.49 (0.67–6.36)	2	0.98	2.05 (0.23–7.39)	2	0.63	3.16 (0.36–11.42)
By duration of diagnosis of PKD
Duration < 1 year
All cancers	63	54.21	1.16 (0.89–1.49)	43	36.82	1.17 (0.84–1.57)	20	17.39	1.15 (0.70–1.78)
Lung & mediastinum	13	6.72	1.93 (1.03–3.31)	7	5.05	1.39 (0.56–2.86)	6	1.67	3.60 (1.31–7.83)
Kidney	3	1.74	1.73 (0.35–5.05)	1	1.07	0.94 (0.01–5.20)	2	0.67	3.00 (0.34–10.82)
Duration 1–3 years
All cancers	49	37.38	1.31 (0.97–1.73)	37	25.38	1.46 (1.03–2.01)	12	12	1.00 (0.52–1.75)
Lung & mediastinum	10	4.81	2.08 (1.00–3.82)	7	3.64	1.92 (0.77–3.96)	3	1.17	2.56 (0.51–7.48)
Kidney	7	1.13	6.19 (2.48–12.75)	4	0.68	5.90 (1.59–15.11)	3	0.45	6.61 (1.33–19.33)

SIR, Standardized Incidence Ratio; PKD, Polycystic Kidney Disease; CI, Confidence Interval; CNS Central Nervous System. . Bold values have symbol indicating .