The Postoperative Recovery Course of Skeletal Muscle Mass in Older Esophageal Cancer Patients

Table 2

Predictors of nonrecovery of SMI 12 months after surgery in older patients.

Variables	Univariate analysis		Multivariate analysis
	Odds ratio (95% CI)	value	Odds ratio (95% CI)	value
Age ≥75 years	0.989 (0.457–2.146)	0.979	0.385 (0.126–1.071)	0.077
Male	0.953 (0.234–2.519)	0.922	0.745 (0.227–2.368)	0.620
Preoperative sarcopenia	0.319 (0.141–0.700)	0.005	0.297 (0.111–0.742)	0.012
CCI ≥2	1.886 (0.733–5.038)	0.193
Squamous cell carcinoma	1.056 (0.298–3.891)	0.932
Clinical stage III-IV	0.767 (0.354–1.652)	0.498
Clinical T3-4	0.568 (0.259–1.227)	0.152
Clinical N positive	0.682 (0.309–1.492)	0.339
Pathological stage III-IV	1.323 (0.549–3.210)	0.531
Pathological T3-4	0.667 (0.289–1.508)	0.334
Pathological N positive	1.496 (0.656–3.263)	0.357
Neoadjuvant chemotherapy	0.269 (0.117–0.596)	0.001	0.248 (0.076–0.735)	0.015
Preoperative high CRP	0.645 (0.234–1.693)	0.381
Preoperative high NLR	0.701 (0.274–1.730)	0.445
Preoperative low PNI	0.352 (0.125–0.903)	0.036^∗	0.341 (0.105–1.027)	0.061
Preoperative low grip force	0.376 (0.113–1.090)	0.085
Preoperative slow gait speed	1.324 (0.536–3.291)	0.541
Postoperative complication	1.622 (0.751–3.544)	0.220
Postoperative pneumonia	0.512 (0.165–1.443)	0.218
Postoperative anastomosis leakage	2.925 (0.884–11.131)	0.092
Postoperative recurrent nerve palsy	1.103 (0.474–2.563)	0.819
Long length of hospital stay (17 days)	0.735 (0.322–1.652)	0.459
Long-term enteral feeding (9 days)	1.522 (0.706–3.315)	0.286
Postoperative major decline in grip force (per 1%)	1.023 (0.984–1.069)	0.265
Postoperative major decline in gait speed (per 1%)	0.987 (0.965–1.006)	0.194
Loss of SMI 4 months after surgery (per 1%)	1.095 (1.042–1.161)	<0.001	1.076 (1.017–1.149)	0.018

CI, confidence interval; CCI, Charlson comorbidity index; CRP, C-reactive protein; NAC, neoadjuvant chemotherapy; NLR, neutrophil-lymphocyte ratio; PNI, prognostic nutritional index; SMI, skeletal muscle mass index. ; .