Impact of Early Chemotherapy Resumption on the Outcome after Staphylococcus aureus Bacteremia in Patients with Solid Tumors: A Retrospective Study in a Single Tertiary Cancer Center in Japan

Table 1

Characteristics of the patients with SAB during chemotherapy.

Characteristics	Total (n = 78)	Chemotherapy after SAB		value
		Resumption (n = 36)	Nonresumption (n = 42)
Age, median (range)	69.0 (28–83)	63.5 (28–78)	71.0 (41–83)	<0.001
Sex (male), n (%)	52 (67)	20 (56)	32 (76)	0.091
ECOG-PS, n (%)				<0.001
0-1	42 (54)	30 (83)	12 (29)
2–4	36 (46)	6 (17)	30 (71)
Cancer type, n (%)
Gastrointestinal cancers^†	43 (55)	23 (64)	20 (48)	0.176
Thoracic cancers^‡	9 (12)	2 (5)	7 (17)	0.166
Breast cancers	7 (9)	5 (14)	2 (5)	0.239
Others^§	19 (24)	6 (17)	13 (31)	0.189
Cancer status, n (%)				1.000
Metastatic	65 (83)	30 (83)	35 (83)
Nonmetastatic	13 (17)	6 (17)	7 (17)
Chemotherapy line, median (range)	1 (1–11)	1 (1–11)	2 (1–6)	0.634
Chemotherapy, n (%)
Cytotoxic agents	70 (90)	35 (97)	35 (83)	0.063
Targeted agents	8 (10)	1 (3)	7 (17)	<0.001
Source of infection, n (%)
CRBSI	51 (65)	27 (75)	24 (57)	0.152
Skin and soft tissue	6 (8)	4 (12)	2 (5)	0.406
Pneumonia	6 (8)	1 (3)	5 (12)	0.209
Unknown origin	10 (13)	2 (5)	8 (19)	0.097
Others	5 (6)	2 (5)	3 (7)	1.000
MRSA, n (%)	14 (18)	5 (14)	9 (21)	0.555
ID consultation, n (%)	73 (94)	36 (100)	37 (88)	0.058
Pitt bacteremia score, median (range)	0 (0–9)	1 (0–4)	0 (0–9)	0.972
Serum albumin, median (range)	2.8 (1.4–5.0)	3.2 (1.7–5.0)	2.7 (1.4–3.9)	0.008

value for comparison between chemotherapy resumption and nonresumption. ^†Colorectal cancer, gastric cancer, pancreatic cancer, esophageal cancer, hepatocellular carcinoma, duodenal cancer, neuroendocrine cancer, and maxillary cancer. ^‡Nonsmall cell lung cancer and small cell lung cancer. ^§Oropharyngeal cancer, bladder cancer, cancers of unknown primary origin, prostate cancer, renal pelvic cancer, testicular cancer, glioma, glioblastoma, rhabdomyosarcoma, Ewing sarcoma, cervical cancer, and melanoma. ECOG, Eastern Cooperative Oncology Group; PS, performance status; SAB, Staphylococcus aureus bacteremia; CRBSI, catheter-related bloodstream infection; MRSA, methicillin-resistant Staphylococcus aureus; ID, infectious disease.