Research Article

Impact of Early Chemotherapy Resumption on the Outcome after Staphylococcus aureus Bacteremia in Patients with Solid Tumors: A Retrospective Study in a Single Tertiary Cancer Center in Japan

Table 2

Characteristics of the patients among early and late resumption of chemotherapy.

CharacteristicsEarly or late chemotherapy resumption value
Early
≦17.5 days
(n = 18)
Late
>17.5 days
(n = 18)

Age, median (range)58.0 (28–71)67.0 (44–78)0.048
Sex (male), n (%)10 (56)10 (56)1.000
ECOG-PS, n (%)0.658
 0-114 (78)16 (89)
 2–44 (22)2 (11)
Cancer type, n (%)
 Gastrointestinal cancers11 (61)12 (67)1.000
 Thoracic cancers2 (11)0 (0)0.243
 Breast cancers4 (22)1 (6)0.338
 Others1 (6)5 (27)0.177
Cancer status, n (%)0.177
 Metastatic17 (94)13 (72)
Nonmetastatic1 (6)5 (28)
Chemotherapy line, median (range)1 (1–11)1.5 (1–5)0.505
Chemotherapy1.000
 Cytotoxic agents18 (100)17 (94)
 Targeted agents0 (0)1 (6)
Source of infection, n (%)
 CRBSI16 (88)11 (61)0.121
 Skin and soft tissue1 (6)3 (16)0.353
 Pneumonia0 (0)1 (6)1.000
 Unknown origin1 (6)1 (6)1.000
 Others0 (0)2 (11)0.486
MRSA, n (%)2 (11)3 (16)1.000
ID consultation, n (%)18 (100)18 (100)1.000
Pitt bacteremia score, median (range)0 (0–4)1 (0–3)0.453
Serum albumin, median (range)3.25 (2.0–5.0)2.9 (1.7–4.2)0.346
Days from negative blood culture to chemotherapy resumption, median (range)13 (0–16)25.5 (19–69)<0.001

ECOG, Eastern Cooperative Oncology Group; PS, performance status; SAB, Staphylococcus aureus bacteremia; CRBSI, catheter-related bloodstream infection; MRSA, methicillin-resistant Staphylococcus aureus; ID, infectious disease.