Effect of CCR2-V64I on the Susceptibility of Patients to Cancer

Table 3

False-positive report probability values for associations between the rs1799864 polymorphism and cancer risk.

Variables	OR (95% CI)	P^a	Power^b	Prior probability
				0.25	0.1	0.01	0.001	0.0001
A versus G
Overall	1.39 (1.14–1.70)	0.001346	0.771	0.005	0.015	0.147	0.636	0.946
Asian	1.57 (1.30–1.91)	0.000098	0.347	0.001	0.003	0.027	0.220	0.739
HB	1.55 (1.20–2.01)	0.000949	0.402	0.007	0.021	0.189	0.702	0.959
OC^a	1.83 (1.39–2.42)	0.000023	0.082	0.001	0.002	0.027	0.216	0.734
AA versus GG
Overall	1.87 (1.30–2.70)	0.000838	0.120	0.021	0.059	0.409	0.875	0.986
Asian	2.30 (1.64–3.24)	0.000002	0.007	0.001	0.002	0.025	0.207	0.724
HB	1.95 (1.27–2.99)	0.002197	0.114	0.054	0.147	0.655	0.950	0.995
BC^b	3.04 (1.09–8.45)	0.033033	0.088	0.530	0.772	0.974	0.997	1.000
GA versus GG
Overall	1.35 (1.03–1.78)	0.033399	0.772	0.115	0.280	0.811	0.977	0.998
Asian	1.35 (1.10–1.67)	0.005689	0.834	0.020	0.058	0.403	0.872	0.986
HB	1.52 (1.02–2.25)	0.036405	0.474	0.187	0.409	0.884	0.987	0.999
OC^a	2.04 (1.47–2.85)	0.000029	0.036	0.002	0.007	0.075	0.450	0.891
AA + GA versus GG
Overall	1.45 (1.11–1.90)	0.007052	0.597	0.034	0.096	0.539	0.922	0.992
Asian	1.52 (1.251.87)	0.000075	0.450	<0.001	0.001	0.016	0.142	0.625
HB	1.68 (1.16–2.43)	0.005871	0.274	0.060	0.162	0.680	0.955	0.995
OCa	2.03 (1.48–2.79)	0.000013	0.031	0.001	0.004	0.039	0.291	0.804
AA versus GA + GG
Overall	1.69 (1.20–2.37)	0.002355	0.245	0.028	0.080	0.488	0.906	0.990
Asian	2.21 (1.58–3.08)	0.000003	0.011	0.001	0.002	0.025	0.204	0.719
HB	1.70 (1.14–2.54)	0.009594	0.271	0.096	0.242	0.778	0.973	0.997
BC^b	2.84 (1.07–7.49)	0.034889	0.098	0.515	0.761	0.972	0.997	1.000

^aChi-square test was adopted to calculate the genotype frequency distributions. ^bStatistical power was calculated using the number of observations in the subgroup and the OR and values in this table. HB: hospital-based study; OC^a: oral cancer; BC^b: bladder cancer.