Treatment and Survival in Acute Leukemia: A New South Wales Study Comparing Adolescents and Young Adults with Children and Adults
Table 2
Treatment history among patients with ALL and AML by age in NSW, 2003–2015.
ALL
AML
Cases with clinical records
0–14 years (n = 754)
15–24 years (n = 152)
25–39 years (n = 125)
0–14 years (n = 141)
15–24 years (n = 115)
25–39 years (n = 249)
Days from diagnosis to treatment start median (IQR)
1 (0–10)
12.5 (0–32)
12.0 (1–40)
0.001
0 (0–19)
39 (4–84)
43 (12–97)
0.001
Time to treatment start
<0.001
<0.001
Within 3 days
475 (63.0)
61 (40.1)
38 (30.4)
90 (63.8)
26 (22.6)
48 (19.3)
>3 days
279 (37.0)
91 (59.9)
87 (69.6)
51 (36.2)
89 (77.4)
201 (80.7)
Initial cancer treatment
0.001
0.007
Chemotherapy
754 (100.0)
151 (99.3)
122 (97.6)
141 (100.0)
105 (91.3)
227 (91.2)
BMT
0 (0)
0 (0)
1 (0.8)
0 (0)
4 (3.5)
12 (4.8)
Radiotherapy
0 (0)
1 (0.7)
2 (1.6)
0 (0)
6 (5.2)
10 (4.0)
Having cancer treatment within 12 month following diagnosis
<0.001
0.024
Yes
750 (98.6)
150 (92.6)
123 (94.6)
137 (92.0)
111 (86.1)
237 (82.3)
No
11 (1.5)
12 (7.4)
7 (5.4)
12 (8.1)
18 (14.0)
51 (17.7)
Treatment type within 12 months following diagnosis
<0.001
0.113
Chemo only
672 (89.6)
100 (66.7)
61 (49.6)
93 (67.9)
66 (59.5)
145 (61.2)
Radio only
0 (0)
0 (0)
2 (1.6)
0 (0)
4 (3.6)
5 (2.1)
BMT only
0 (0)
0 (0)
0 (0)
0 (0)
2 (1.8)
3 (1.3)
Chemo + radio
64 (8.5)
35 (23.3)
44 (35.8)
8 (5.8)
15 (13.5)
28 (11.8)
Chemo + BMT
12 (1.6)
10 (6.7)
14 (11.4)
36 (26.3)
24 (21.6)
53 (22.4)
Chemo + radio + BMT
2 (0.3)
5 (3.3)
2 (1.6)
0 (0)
0 (0)
3 (1.3)
Treatment regimen
<0.001
0.316
Chemotherapy only
672 (89.6)
100 (66.7)
61 (49.5)
93 (67.9)
66 (59.5)
145 (61.2)
Chemotherapy + BMT/radio
78 (10.4)
50 (33.3)
62 (50.4)
44 (32.1)
45 (40.5)
92 (38.8)
Numbers in the table: case number (%). Data from linked treatment record. from Kruskal Wallis test for “Days from diagnosis to treatment start median (IQR)”; from chi-square test (or Fisher’s exact chi-square test when a cell count <5) for the others. Abbreviations: ALL: acute lymphoid leukemia; AML: acute myeloid leukemia; IQR: interquartile range; BMT: bone marrow transplant.
