Identification of a Novel Circadian Rhythm-Related Signature for Predicting Prognosis and Therapies in Hepatocellular Carcinoma Based on Bulk and Single-Cell RNA Sequencing

Figure 2

Identification of the key modules and hub genes related to circadian rhythm. (a) Sample clustering to identify the outliers. (b) The scale-free index for soft-thresholding powers. (c) A dendrogram based on hierarchical clustering with optimal soft thresholds. (d) Heatmap of the correlation between modules and features (CR score). (e) The histogram of the gene significance (GS) across modules. (f, g) Scatter plot of the correlation between module membership (MM) and gene significance (GS) of score in brown and green modules, respectively.