Identification of a Novel Circadian Rhythm-Related Signature for Predicting Prognosis and Therapies in Hepatocellular Carcinoma Based on Bulk and Single-Cell RNA Sequencing

Figure 3

Dimensionality reduction, cell annotation, and identification of the CR score-related cell subpopulations. (a) Left: the UMAP of the 28 cell clusters. Right: the UMAP of 11 cell types was annotated by different markers. (b) The bubble plot shows the GO-BP analysis of DEGs for each cell type. (c) Left: the UMAP of the CR score for each cell type. Right: the UMAP of the cell types distributed into the high-CR score and low-CR score groups. (d, e) The bubble plot shows the GO (BP, CC, and MF) and KEGG enrichment analyses based on upregulated and downregulated DEGs between high-CR score and low-CR score groups, respectively.

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