Exploring Cinnamic Acids as Potent Antimetastatic Agents for Cancer Therapy: Molecular Docking and Dynamic Simulation against MMP2

Figure 5

Following a 100 ns MD simulation, the superimposition of structures was performed for (a) free MMP2, (b) MMP2 with cynarin, and (c) MMP2 with oleandrin. The protein chains were depicted in green and purple to indicate their states before and after the MD analysis. Additionally, the ligands were portrayed in black and yellow to represent their conditions before and after the MD simulations. MMP2, matrix metalloproteinase 2; MD, molecular dynamics.

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