|
| Preferred regimens | First step | Cycle |
|
| Dose-dense AC followed by paclitaxel | Doxorubicin 60 mg/m2 IV day 1 | |
| Cyclophosphamide 600 mg/m2 IV day 1 | Cycled every 14 days for 4 cycles |
| Paclitaxel 175 mg/m2 by 3 h IV infusion day 1 | Cycled every 14 days for 4 cycles |
|
| Dose-dense AC followed by weekly paclitaxel | Doxorubicin 60 mg/m2 IV day 1 | |
| Cyclophosphamide 600 mg/m2 IV day 1 | Cycled every 14 days for 4 cycles |
| Paclitaxel 80 mg/m2 by 1 h IV infusion weekly | 12 weeks |
|
| TC | Docetaxel 75 mg/m2 IV day 1 | |
| Cyclophosphamide 600 mg/m2 IV day 1 | Cycled every 21 days for 4 cycles |
|
| Preoperative pembrolizumab + chemotherapy followed by adjuvant pembrolizumab | Pembrolizumab 200 mg IV day 1 | |
| Paclitaxel 80 mg/m2 IV days 1, 8, 15 | |
| Carboplatin AUC 5 IV day 1 | Cycled every 21 days for 4 cycles (cycles 1–4) |
| Pembrolizumab 200 mg IV day 1 | |
| Doxorubicin 60 mg/m2 IV day 1 or epirubicin 90 mg/m2 IV day 1 | |
| Cyclophosphamide 600 mg/m2 IV day 1 | Cycled every 21 days for 4 cycles (cycles 5–8) |
| Adjuvant pembrolizumab 200 mg IV day 1 | Cycled every 21 days for 9 cycles |
|
| Capecitabine | 1,000–1,250 mg/m2 PO twice daily on days 1–14 | Cycled every 21 days for 6–8 cycles |
|
| Olaparib | 300 mg PO twice daily | Cycled every 28 days for 1 y |
|
