Clinical Specimens are the Pool of Multidrug- resistant Pseudomonas aeruginosa Harbouring oprL and toxA Virulence Genes: Findings from a Tertiary Hospital of Nepal
Table 3
Antibiotic susceptibility pattern of P. aeruginosa.
Antibiotics
Antibiotic class
Mode of action
Sensitive, n (%)
Intermediate, n (%)
Resistant, n (%)
Aztreonam
Monobactams
Inhibition of cell wall synthesis
58 (66.66)
21 (24.13)
8 (9.19)
Ceftazidime
Cephalosporins
61 (70.11)
0 (0)
26 (29.88)
Cefixime
0 (0)
0 (0)
87 (100)
Carbenicillin
Penicillins
30 (34.48)
16 (18.39)
41 (47.12)
Piperacillin
54 (62.06)
10 (11.49)
23 (26.43)
Piperacillin-tazobactam
Penicillin combinations
37 (78.72)
1 (2.12)
9 (19.14)
Imipenem
Carbapenems
63 (72.41)
0 (0)
24 (27.58)
Polymyxin
Polypetides
73 (83.90)
14 (16.09)
0 (0)
Ciprofloxacin
Fluoroquinolones
Inhibition of nucleic acid synthesis
59 (67.81)
1 (1.14)
27 (31.03)
Norfloxacin
56 (64.36)
0 (0)
31 (35.36)
Gentamicin
Aminoglycosides
Inhibition of protein synthesis
69 (79.31)
0 (0)
18 (20.68)
Tobramycin
71 (81.60)
0 (0)
16 (18.39)
Nitrofurantoin
Nitrofurans
Inhibition of bacterial ribosomes and other macromolecules
0 (0)
0(0)
40 (100)
Note: The antimicrobial susceptibility of 40 isolates was tested against nitrofurantoin while the antimicrobial susceptibility of the remaining 47 isolates was performed against piperacillin-tazobactam.
