Association between Novel Marker (Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio, and Delta Neutrophil Index) and Outcomes in Sudden Cardiac Arrest Patients
Table 1
Baseline characteristics of the enrolled patients and comparison of variables by outcomes.
All patients
Primary outcome
Secondary outcome
Tertiary outcome
No-ROSC (N = 415)
ROSC (N = 324)
value
Death (n = 230)
Survival to discharge (n = 60)
value
Poor (N = 36)
Good (N = 24)
value
Age (years)
72 (19–98)
75 (19–98)
68 (20–96)
0.007
70 (20–96)
57 (22–87)
≤0.001
65.5 (22–87)
49 (29–82)
0.004
Male sex, n (%)
444 (60.1%)
254 (61.2%)
190 (58.6%)
0.529
133 (57.8%)
40 (66.7%)
0.273
25 (69.4%)
15 (62.5%)
0.780
Hypertension
325 (44.0%)
188 (45.3%)
137 (42.3%)
0.456
98 (42.6%)
24 (40.0%)
0.828
17 (47.2%)
7 (29.2%)
0.259
Diabetes mellitus
216 (29.2%)
114 (27.5%)
102 (31.5%)
0.268
69 (30.0%)
20 (33.3%)
0.733
13 (36.1%)
7 (29.2%)
0.780
Coronary heart disease
73 (9.9%)
42 (10.1%)
31 (9.6%)
0.900
24 (10.4%)
5 (8.3%)
0.809
2 (5.6%)
3 (12.5%)
0.380
CVA
69 (9.3%)
42 (10.1%)
27 (8.3%)
0.483
20 (8.7%)
4 (6.7%)
0.807
3 (8.3%)
1 (4.2%)
0.643
Previous CPC
CPCs1-2
681 (92.2%)
386 (93.0%)
295 (91.0%)
209 (90.9%)
58 (96.7%)
34 (94.4%)
24 (100%)
CPC 3
58 (7.8%)
29 (7.0%)
29 (9.0%)
0.397
21 (9.1%)
2 (3.3%)
0.226
2 (5.6%)
0
0.512
Bystander CPR
406 (54.9%)
219 (52.8%)
187 (57.7%)
0.205
103 (44.8%)
23 (38.3%)
0.452
21 (58.3%)
16 (66.7%)
0.704
Witnessed
392 (53.0%)
197 (47.5%)
195 (60.2%)
≤ 0.001
134 (58.3%)
39 (65.0%)
0.424
22 (61.1%)
17 (70.8%)
0.619
Location
Public
290 (39.2%)
155 (37.3%)
135 (41.7%)
89 (38.7%)
30 (50.0%)
20 (55.6%)
10 (41.7%)
Home
449 (60.8%)
260 (62.7%)
189 (58.3%)
0.264
141 (61.3%)
30 (50.0%)
0.150
16 (44.4%)
14 (58.3%)
0.429
Presenting rhythm
Asystole
446 (60.4%)
296 (71.3%)
150 (46.3%)
112 (48.7%)
19 (31.7%)
16 (44.4%)
3 (12.5%)
PEA
228 (30.9%)
92 (22.2%)
136 (42.0%)
96 (41.7%)
26 (43.3%)
17 (47.2%)
9 (37.5%)
Pulseless VT
6 (0.8%)
3 (0.7%)
3 (0.9%)
2 (0.9%)
1 (1.7%)
0
1 (4.2%)
Ventricular fibrillation
59 (8.0%)
24 (5.8%)
35 (10.8%)
≤0.001
20 (8.7%)
14 (23.3%)
0.007
3 (8.3%)
11 (45.8%)
0.002
Frequency defibrillation
0 (0–38)
1.5 (0–6)
0 (0–38)
0.870
0 (0–38)
0 (0–11)
0.084
0 (0–11)
0 (0–6)
0.003
Total CPR time (min)
42 (1–194)
52 (2–194)
31 (1–134)
≤0.001
32 (1–134)
25.5 (1–72)
≤0.001
29 (2–67)
13.5 (1–72)
0.018
C-reactive protein (mg/dL)a
0.95 (0.29–45.6)
0.81 (0.02–45.6)
1.17 (0.29–39.9)
0.091
1.46 (0.29–39.9)
0.40 (0.29–21.4)
≤0.001
1.10 (0.29–21.4)
0.29 (0.29–19.7)
0.007
Delta neutrophil index (%)b
0.00 (0.00–57.6)
0.00 (0.00–57.6)
0.45 (0.00–56.2)
0.101
0.95 (0.00–56.2)
0.00 (0.00–40.9)
0.005
0.20 (0.00–16.9)
0.00 (0.00–40.9)
0.189
Neutrophil count (×109/L)
5.43 (0.06–43.67)
4.98 (0.06–43.67)
6.30 (0.12–41.11)
0.001
6.34 (0.12–41.11)
7.58 (0.29–32.81)
0.262
7.48 (0.29–29.64)
7.58 (1.25–32.81)
0.608
Lymphocyte count (×109/L)
4.53 (0.19–19.82)
4.64 (0.19–13.23)
4.34 (0.58–19.82)
0.386
4.21 (0.60–19.82)
5.02 (0.58–13.29)
0.736
7.84 (0.94–13.29)
4.32 (0.58–10.12)
0.163
Platelet count (×109/L)
178 (5–890)
167 (5–643)
188 (11–890)
≤0.001
179 (11–890)
211 (42–431)
0.002
207.5 (110–431)
220.5 (42–377)
0.460
Platelet-lymphocyte ratio
38.24 (1.94–535.29)
34.57 (1.94–535.29)
42.41 (4.21–508.7)
0.006
41.85 (4.21–508.70)
48.83 (7.65–329.67)
0.101
40.53 (14.52–274.34)
60.11 (7.65–329.67)
0.156
Neutrophil-lymphocyte ratio
1.22 (0.04–24.60)
1.08 (0.04–21.48)
1.38 (0.09–24.60)
≤0.001
1.39 (0.09–18.24)
1.69 (0.04–24.6)
0.411
1.43 (0.22–21.15)
2.02 (0.04–24.60)
0.566
CPC, cerebral performance category; CPR, cardiopulmonary resuscitation; PEA, pulseless electrical activity; VT, ventricular tachycardia; ROSC, return of spontaneous circulation. Including death in the emergency department and death after hospitalization. aNormal reference range: <0.3. bNormal reference range: <2.6 (%).
