Research Article
A Novel Nomogram for Predicting Survival in Patients with Severe Acute Pancreatitis: An Analysis Based on the Large MIMIC-III Clinical Database
Table 1
Baseline characteristics, vital signs, laboratory parameters, and outcomes of patients with acute pancreatitis.
| | Variables | Classification | Patients | P | | Training set (%) | Validation set (%) |
| | Total | — | 595 | 255 | — | | Age | — | 60 (48–71) | 59 (45–71) | 0.450 | | LOS | — | 4 (2–12) | 3 (2–10) | 0.128 | | Weight | — | 81 (68–97) | 79 (68–91) | 0.145 |
| | Gender | Male | 353 (59.3) | 130 (51.0) | 0.024 | | Female | 242 (40.7) | 125 (49.0) |
| | Ethnicity | White | 400 (67.2) | 168 (65.9) | 0.790 | | Black | 58 (9.7) | 23 (9.0) | | Other | 137 (23.0) | 64 (25.1) |
| | Admission type | Elective | 15 (2.5) | 11 (4.3) | 0.204 | | Emergence | 557 (93.6) | 230 (90.2) | | Urgent | 23 (3.9) | 14 (5.5) |
| | Insurance | Medicare | 274 (46.1) | 116 (45.5) | 0.908 | | Private | 214 (36.0) | 95 (37.3) | | Medicaid | 73 (12.3) | 33 (12.9) | | Government | 27 (4.5) | 8 (3.1) | | Self-pay | 7 (1.2) | 3 (1.2) |
| | Marital status | Married | 366 (61.5) | 166 (65.1) | 0.580 | | Unmarried | 184 (30.9) | 73 (28.6) | | Other | 45 (7.6) | 16 (6.3) |
| | Explicit sepsis | Yes | 470 (79.0) | 198 (77.6) | 0.661 | | No | 125 (21.0) | 57 (22.4) |
| | Infection | Yes | 217 (36.5) | 96 (37.6) | 0.745 | | No | 378 (63.5) | 159 (62.4) |
| | Organ dysfunction | Yes | 248 (41.7) | 101 (39.6) | 0.573 | | No | 347 (58.3) | 154 (60.4) |
| | Vent | Yes | 307 (51.6) | 133 (52.2) | 0.881 | | No | 288 (48.4) | 122 (47.8) |
| | Comorbidities | Diabetes | 133 (22.4) | 57 (22.4) | 0.195 | | Hypertension | 311 (52.3) | 142 (55.7) | 0.244 | | Liver disease | 140 (23.5) | 58 (22.7) | 0.255 | | Neurological | 81 (13.6) | 28 (11.0) | 0.279 | | Renal failure | 87 (14.6) | 33 (12.9) | 0.233 | | Coagulopathy | 120 (20.2) | 62 (24.3) | 0.252 | | Alcohol abuse | 140 (23.5) | 65 (25.5) | 0.240 | | Fluid electrolyte | 282 (47.4) | 135 (52.9) | 0.253 | | Chronic pulmonary | 102 (17.1) | 35 (13.7) | 0.267 | | Cardiac arrhythmias | 179 (30.1) | 85 (33.3) | 0.318 | | CHF | 145 (24.4) | 61 (23.9) | 0.220 |
| | Scoring systems | SAPSII | 37 (27–47) | 35 (26–44) | 0.208 | | Elixhauser score | 8 (4–15) | 9 (2–15) | 0.636 |
| | Laboratory events | PT | 14.1 (12.9–16.0) | 14.1 (13.0–16.1) | 0.970 | | PTT | 29.5 (25.7–34.1) | 28.9 (25.8–34.5) | 0.930 | | Bilirubin | 0.9 (0.5–2.2) | 0.8 (0.4–1.9) | 0.174 | | Chloride | 103.0 (99.0–108.0) | 103.0 (98.0–108.0) | 0.368 | | ALT | 42.0 (23.0–138.0) | 41.0 (19.0–104.0) | 0.242 | | AST | 59 (28.0–146.0) | 54.0 (27.0–129.0) | 0.414 | | Calcium | 8.3 (7.6–8.9) | 8.3 (7.7–9.0) | 0.529 | | Anion gap | 16.0 (13.0–19.0) | 16.0 (14.0–19.0) | 0.419 | | Bicarbonate | 23.0 (19.0–26.0) | 23.0 (20.0–26.0) | 0.548 | | Creatinine | 1.1 (0.8–1.9) | 1.1 (0.7–2.0) | 0.745 | | Glucose | 135.0 (105.0–180.0) | 125.0 (98.0–163.0) | 0.012 | | Potassium | 4.1 (3.7–4.6) | 4.1 (3.7–4.6) | 0.777 | | Sodium | 138.0 (135.0–141.0) | 138.0 (135.0–141.0) | 0.990 | | Hematocrit | 35.2 (30.3–40.7) | 35.1 (31.3–40.3) | 0.819 | | Hemoglobin | 11.8 (10.1–13.7) | 11.9 (10.3–13.7) | 0.602 | | Platelet | 226.0 (158.0–320.0) | 220.0 (156.0–292.0) | 0.668 | | RDW | 14.5 (13.6–15.7) | 14.5 (13.5–15.9) | 0.428 | | WBC | 12.6 (8.5–17.6) | 12.6 (8.8–17.4) | 0.794 |
| | Vital signs | MBP | 80 (73–90) | 78 (71–89) | 0.147 | | SPO2 | 97 (95–98) | 97 (95–99) | 0.664 | | Temperature | 37.0 (36.6–37.6) | 37.0 (36.6–37.6) | 0.909 | | Heart rate | 96 (83–109) | 94 (82–109) | 0.050 | | Respiratory rate | 21 (17–24) | 20 (18–24) | 0.403 |
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LOS: length of stay; Vent: mechanical ventilation; CHF: chronic heart failure; SAPSII: Simplified Acute Physiology Score II; RDW: red blood cell distribution width; WBC: white blood cell; MBP: mean blood pressure.
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