Research Progress on the Mechanism and Management of Septic Cardiomyopathy: A Comprehensive Review

Table 3

Treatment strategy of septic cardiomyopathy.

Treatment strategy		Benefits	Problems
Noninvasive	Fluid resuscitation	Increasing preload may elevate cardiac output	Excessive fluid may lead to higher mortality
	Vasopressors	May reverse hypotension due to the vasoconstrictive effects	Increased afterload may “unmask” cardiac dysfunction
	Dobutamine	May improve cardiac parameters	Risk of tachycardia, impact on outcome is ambiguous
	Levosimendan	May increase cardiac output and systemic hemodynamics	No change on mortality
	β-blockers	May decrease myocardial demand and improve outcome	Negative inotropic effect, may aggravate hemodynamic instability
	Vitamin C protocol	May improve organ function and outcome	More clinical research is needed
Invasive	IABP	May provide supportive care and mortality benefits	Invasive, may cause severe complications
	ECMO
	Polymyxin-B hemoperfusion

IABP, intra-aortic balloon pumping; ECMO, extracorporeal membrane oxygenation.