Research Article

Changes in Liver and Splenic Stiffness after Direct-Acting Antiviral Therapy in Chronic Hepatitis C: A Single-Centre, Prospective, Observational Study

Table 3

Univariate and multivallate analyses of factors associated with remaining portal hypertension in patients with a spleen stiffness value of ≥3.4 m/s at pretreatment (high SSM group, n =48).

UnivariateMultivariate
FactorOR95% CIp-valueOR95% CIp-value

Age<74 years1.520.46-5.040.49
Sex (female)4.041.05-15.580.034
LSM ≥1.93 m/s9.691.86-50.420.00187.611.40-41.300.019
ALB ≥3.8 g/dL1.980.63-6.260.24
ALT ≥35 IU/L4.061.22-13.580.0192.930.79-10.830.11
PLT<12.6 × 104/μL6.051.59-23.010.0048

Abbreviations: SSM, spleen stiffness measurement; LSM, liver stiffness measurement; ALB, albumin; ALT, alanine aminotransferase; PLT, platelet count; OR, odds ratio; 95% CI, 95% confidence interval. P-values were assessed by the likelihood-ratio test.