Changes in Liver and Splenic Stiffness after Direct-Acting Antiviral Therapy in Chronic Hepatitis C: A Single-Centre, Prospective, Observational Study

Table 3

Univariate and multivallate analyses of factors associated with remaining portal hypertension in patients with a spleen stiffness value of ≥3.4 m/s at pretreatment (high SSM group, n =48).

	Univariate			Multivariate
Factor	OR	95% CI	p-value	OR	95% CI	p-value
Age<74 years	1.52	0.46-5.04	0.49
Sex (female)	4.04	1.05-15.58	0.034
LSM ≥1.93 m/s	9.69	1.86-50.42	0.0018	7.61	1.40-41.30	0.019
ALB ≥3.8 g/dL	1.98	0.63-6.26	0.24
ALT ≥35 IU/L	4.06	1.22-13.58	0.019	2.93	0.79-10.83	0.11
PLT<12.6 × 10^4/μL	6.05	1.59-23.01	0.0048

Abbreviations: SSM, spleen stiffness measurement; LSM, liver stiffness measurement; ALB, albumin; ALT, alanine aminotransferase; PLT, platelet count; OR, odds ratio; 95% CI, 95% confidence interval. P-values were assessed by the likelihood-ratio test.