Nicotine Enemas for Active Crohn's Colitis: An Open Pilot Study

Figure 2

Adverse events during study. Adverse events experienced during nicotine enema treatment with the number of patients affected in each case.“Sleep prob” refers to disturbed sleep or vivid dreams.The “rash” was a 2 cm diameter erythematous maculopapular lesion on the forearm of a patient which resolved spontaneously.