Involvement of COX-2/PGE₂ Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer

Figure 3

Inhibition of MMP-9 expression by NS398 or indomethacin (a) and (b) MMP-9 expression was inhibited in BxPC-3 and Capan-1 cells after treatment with NS398 (*𝑃<0.01, resp., versus control ) or indomethacin (*𝑃<0.01, resp., versus control). (c), (d) PGE₂ protein levels were decreased in BxPC-3 and Capan-1 after treatment with NS398 for 12 hours (*𝑃<0.01, resp., versus control) or 24 hours (*𝑃<0.01, resp., versus control). Data are expressed as mean ± SD, 𝑛=3. NS: NS398; indo: indomethacin.

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