Association between Genetic Instability and Helicobacter pylori Infection in Gastric Epithelial Dysplasia

Table 2

LINE-1 methylation level according to genetic instability (chromosomal instability and microsatellite instability) in gastric epithelial dysplasias categorized by the revised Vienna classification.

		Category 3 GED			Category 4 GED
		𝑛	LINE-1	P value	𝑛	LINE-1	P value
			methylation			methylation
Chromosomal instability	LOH (−)	8	44.36 ± 3.43	0.33	9	39.13 ± 4.39	0.58
	LOH-L	27	45.61 ± 2.39		20	38.42 ± 3.47
	LOH-H	15	44.02 ± 5.79		21	39.35 ± 3.66
Microsatellite state	MSS	35	45.68 ± 4.41	0.05*	29	38.85 ± 4.56	0.85
	MSI	15	43.18 ± 3.66		21	39.09 ± 3.98

LOH: loss of heterozygosity; LOH-L: LOH (+) <3 loci; LOH-H: LOH (+) >4 loci; MSS: microsatellite stable; MSI: microsatellite instable, *statistically significant.