The Role of e-NOS in Chronic Cholestasis-Induced Liver and Renal Injury in Rats: The Effect of N-Acetyl Cysteine

Figure 1

(a) Dilated common bile duct in rats (4 weeks after CBDL). (b) (Group A), (c) (Group B), and (d) (Group C): histological changes among groups (1 week after the CBDL). Minimal dilatation in the portal region, a few mononuclear cells, and ductal proliferation in portal regions are seen (H&E, ×200). (e) (Group B) and (f) (Group C): more intense inflammation and more ductile proliferation were observed (2 weeks after CBDL) (H&E, ×200). (g) (Group B): severe bridging fibrosis with enlargement of the portal region (H&E, ×200). (h) (Group C): no bridging fibrosis with enlargement of the portal region (H&E, ×200). (i) (Group B).

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