Genome-Wide Expression of MicroRNAs Is Regulated by DNA Methylation in Hepatocarcinogenesis
Table 1
Fold change of top 25 significant miRNAs* in the discovery set ( pairs).
miRNAs†
Tumor
Nontumor
Fold change**
P values
miR-196b
−8.94 (1.17)
−13.38 (1.50)
18.00
miR-10b#
−10.01 (1.92)
−13.16 (1.83)
8.94
miR-182
−10.83 (1.68)
−13.45 (2.72)
8.34
miR-183
−13.03 (1.31)
−15.00 (1.66)
8.00
miR-1180
−10.25 (1.01)
−12.13 (1.16)
3.73
miR-18a
−7.74 (1.33)
−9.10 (0.78)
2.57
miR-99a#
−10.87 (0.98)
−9.27 (0.90)
−2.50
miR-30a-3p
−5.17 (0.86)
−3.84 (0.69)
−2.51
miR-381
−14.24 (0.85)
−12.89 (1.17)
−2.55
miR-100
−5.24 (0.76)
−3.83 (0.88)
−2.66
miR-125b
−4.97 (1.04)
−3.44 (0.88)
−2.89
miR-99a
−5.57 (0.74)
−4.26 (0.83)
−3.01
miR-378-002243‡
−4.69 (1.14)
−3.03 (0.84)
−3.14
miR-130a
−9.39 (1.02)
−7.72 (1.04)
−3.18
miR-422a†
−8.72 (1.42)
−7.04 (1.02)
−3.20
let-7c
−8.62 (1.08)
−6.88 (0.50)
−3.32
miR-10a
−8.30 (1.37)
−6.45 (1.21)
−3.58
miR-223
−1.79 (1.36)
0.18 (0.79)
−3.89
miR-424
−11.84 (1.07)
−9.86 (1.21)
−3.94
miR-511
−11.34 (1.16)
−9.15 (0.68)
−4.56
miR-139-5p
−7.00 (1.37)
−4.76 (0.94)
−4.69
miR-199a-3p
−5.27 (2.45)
−2.68 (1.14)
−6.02
miR-486
−8.81 (1.10)
−6.21 (1.90)
−6.06
miR-378-000567†
−11.65 (2.30)
−8.89 (2.23)
−6.82
miR-144#
−9.98 (1.66)
−7.06 (1.49)
−7.52
False discovery rate (FRD) <0.05; †“miR-” refers to the mature miRNA; **fold change >0 indicates miRNAs overexpression, <0 indicates miRNAs downexpression; ‡not included in the Infinium Methylation 450K assay; the miRNA following # indicates a miRNA expressed at low levels relative to the same miRNA without #, which shares a pre-miRNA hairpin.
