CNP-pGC-cGMP-PDE3-cAMP Signal Pathway Upregulated in Gastric Smooth Muscle of Diabetic Rats

Figure 1

Effect of CNP on the spontaneous contraction of gastric antral smooth muscle in control and diabetic rats. (a) CNP significantly inhibited the spontaneous contraction of gastric antral smooth muscle in both control and diabetic rats. (b) CNP caused significantly more inhibition on the amplitude of the contraction in diabetic rats than in controls (, ). (c) CNP caused significantly more inhibition on the frequency of the contraction in diabetic rats than in controls (, ). (d) CNP decreased the basal tension, which was more significant in diabetic rats than in controls (, ). (e) The duration of CNP-induced inhibition of gastric smooth muscle contraction was significantly longer in diabetic rats than in controls (, ).

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