CNP-pGC-cGMP-PDE3-cAMP Signal Pathway Upregulated in Gastric Smooth Muscle of Diabetic Rats

Figure 4

Expression of PDE3 in the gastric smooth muscle. (a) PDE3 immunoreactivity in gastric smooth muscle was lower in the diabetic rats than in controls (bars = 20 μm). (b) The mRNA level of PDE3 in the gastric smooth muscle was downregulated in the diabetic rats (, ). (c) The protein level of PDE3 detected by Western blotting analysis in the gastric smooth muscle was significantly lower in the diabetic rats than in controls (, ).

(a)

(b)

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