Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis

Table 1

Apoptotic and antiapoptotic gene expression in chronic HCV-mediated liver injury and cirrhosis.

Gene/product	Function in CHC	Role
Apoptotic
IFN-	Upregulation	Cytokine
IRF-7	Upregulation	Transcription factor
Cytoplasmic dynein light chain	Upregulation	Motor protein, centrosome assembly
AML1/RUNX1	Upregulation	Transcription factor
Dr-nm23/NME3	Upregulation	Inhibition of granulocyte differentiation
Plasminogen activator inhibitor-2	Upregulation	Fibrinolysis, tissue repair
SARP3	Upregulation	Cellular growth and differentiation
CTGF	Upregulation	Tissue fibrosis, cell adhesion
CDKN1C	Upregulation	Tumor suppressor
CDC42	Downregulation	Cell cycle progression
Antiapoptotic
Bcl-2	Upregulation	Cell proliferation, oncogenesis
Bcl-w	Upregulation	Cell proliferation
E2F transcription factor	Upregulation	Cell cycle progression
NF-B	Upregulation	Cell proliferation, regeneration
Tissue metalloproteinase inhibitor	Upregulation	Cell-cell interaction, anti-inflammatory cell response

CHC: chronic HCV-induced hepatitis; IFN: interferon; IRF: interferon regulatory factor; AML1: acute myeloid leukemia 1 protein; RUNX1: Runt-related transcription factor 1; NME3: nonmetastatic cells protein 3; SARP3: secreted apoptosis-related protein 3; CTGF: connective tissue growth factor; CDKN1C: cyclin-dependent kinase inhibitor 1C; CDC: cell division cycle 42 GTP-binding protein.