DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon

Figure 2

DUOX2 detected by IHC in different tissues of esophagus, stomach, colon, and liver. In normal epithelium of esophagus DUOX2 protein was not detected by IHC (a1); in the columnar epithelium of Barrett esophagus the expression of DUOX2 was mainly located in the apical membrane of epithelial cell (a2); in adjacent nonmalignant gastric tissue epithelial cells were stained negatively with DUOX2 antibody; some unidentified cells were stained positively in lamina propria (b1, arrows); in gastric cancer DUOX2 was mainly found in cell plasma of tumor cells (b2); DUOX2 was at a low level and was mainly at the edge brush of epithelial cells, endocrine cells were strongly stained for DUOX2 (c1, arrows), and DUOX2 expression was higher in CRC; there were nuclei stained with DUOX2 antibody (c2). In hepatic carcinoma and its adjacent nonmalignant tissue there was no DUOX2 IHC staining (d1 and d2). Magnification: ×400.