Gastroenterology Research and Practice

Research Article

Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans

Table 4

(a) Significant regulators identified by IPA. (b) Genes’ mapping to known molecular pathways.
(a)
Gene name Crosstalk genes
L3MBTL1MMP3
NKX6-2GCG, CREB1
PREX1HDAC1, AKT1
TRAF7IKBKB
PRDM14 DLG4
NEFMSMAD2
(b)
PathwaysDifferentially methylated genes
Wnt/β-cateninL3MBTL1, NKX6-2, PREX1,TRAF7, and NEFM
P53L3MBTL1, PREX1, TRAF7, and NEFM
TGF-βL3MBTL1, PREX1, TRAF7, and NEFM
VEGFL3MBTL1, PREX1, TRAF7, and NEFM
NF-kβPREX1, TRAF7, and NEFM
HippoPREX1, PRDM14, and NEFM
JAK/STAT3L3MBTL1, PREX1, TRAF7, and NEFM
P38 MAPKL3MBTL1, NKX6-2, PREX1, TRAF7, PRDM14, and NEFM
PI3K/AKTL3MBTL1, PREX1, TRAF7, and NEFM
Common pathways.