Review Article
Outcomes of Radiofrequency Ablation for Dysplastic Barrett’s Esophagus: A Comprehensive Review
Table 2
Efficacy of radiofrequency ablation for Barrett’s esophagus with high-grade dysplasia/intramucosal carcinoma.
| | Author/year | Study design | Setting | Number | BE length in cm | ER before RFA | Efficacy
(end of treatment) | Recurrence | Complications | | CE-D (%) | CE-IM (%) | D (%) | IM (%) | |
| | Gondrie et al. 2008 [17] | PS | SC | 11 | 7 (median) | 58% | 91% | 100% | 0% | 0% | 9% (1 stricture) | | Gondrie et al. 2008 [18] | PS | SC | 9 | 5 (median) | 55% | 88.9 % | 100% | 0% | 0% | 0% | | Ganz et al. 2008 [19] | RS | MC | 142 | 6 (median) | 17% | 80.4% | 54.3% | NR | NR | 0.4 % (1 stricture) | | Sharma et al. 2009 [10] | PS | SC | 24 | 6 (median) | 8% | 79% | 67% | NR | NR | 0% | | Shaheen et al. 2009 [8] | RCT | MC | 42 | 5.3 (mean) | NR | 81% | 74% | — | — | 9.5% (5 stricture, 1 bleeding, 2 chest | | Pouw et al. 2010 [11] | PS | MC | 24 | 8 (median) | 96% | 95% | 88% | 0% | 12.5% | 8% (1 bleeding, 1 | | Van Vilsteren et al. 2011 [20] | RCT | MC | 22 | 4 (median) | 82% | 96% | 96% | 0% | 0% | 31.8% (3 bleeding, 3 stenosis, 1 acute nontransmural laceration) | | Lyday et al. 2010 [12] | RS | MC | 10 | 3 (median) | 10% | 100% | 80% | NR | NR | 3.9% (9 stricture, 3 bradycardia, 4 bleeding, 1 superficial mucosal injury, 1 | | Shaheen et al. 2011 [13] | RCT | MC | 54 | 5.2 (mean) | 8% | 92.6% | 89% | 7.4% | 11% | 10.9% (1 bleeding, 3 chest pain, 9 esophageal | | Okoro et al. 2012 [14] | RS | SC | 39 (ER+RFA) | 6.9 (mean) | 100% | 74.4% | 41% | NR | NR | 16.6% (10 stricture, 5 chest | | 8 (RFA) | 4.5 (mean) | 0% | 87.5% | 87.5% | | Bulsiewicz et al. 2013 [15] | RS | SC | 166 | 4 (mean) | 39.2% | 84.9% | 78.3% | NR | NR | 8.2% (18 stricture, 2 | | Dulai et al. 2013 [16] | RS | SC | ULSBE: 25 | 10.8 (media) | | 88% | | 0% | 23% | 21% (7% postablative mucosal tears and 14% | | LSBE: 26 | 4.7 (media) | | 84% | | 0% | 16% | | Haidry et al. 2013 [21] | RS | MC | 335 | 5.8 (media) | 49% | 81% | 62% | 6% | 9% | 9.3% (30 stricture, 1 perforation) | | Strauss et al. 2014 [22] | RS | MC | 36 | 3.5 (mean) | 86% | 89% | 75% | 9% | 27% | 22% (7 stricture, 1 bleeding) | | Perry et al. 2014 [23] | RS | SC | 17 | 5 (median) | 53% | 88% | 65% | 17.6% | 46% | 0% | | Lada et al. 2014 [24] | RS | SC | 57 | 5.1 (mean) | 49% | 79% | 49% | 21% | 7.6% | 3.8% (2 stricture, 2 chest pain) | | Le Page et al. 2015 [25] | RS | SC | 36 | 5 (median) | 47.8% | 97% | 61% | 6% | NR | 16% (6 chest pain, 1 stricture, 1 bleeding) |
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data.
BE: Barrett’s esophagus; ER: endoscopic mucosal resection; RFA: radiofrequency ablation; RCT: randomized controlled trial; PS: prospective study; RS: retrospective study; SC: single center; MC: multicenter; ULSBE: ultra-long segment Barrett’s esophagus; LSBE: long segment Barrett’s esophagus; NR: not reported; CE-D: complete eradication of dysplasia; CE-IM: complete eradication of intestinal metaplasia; D: dysplasia; IM: intestinal metaplasia. : efficacy at end of follow-up.
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