Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage

Table 1

Inclusion and exclusion criteria for NAFLD, hepatitis, and cirrhosis patients.

NAFLD	Inclusion criteria	No alcohol history or consuming of alcohol < 210 g/week for male and < 140 g/week for female
		Ultrasound, CT, MRI, or liver biopsy prompted fatty liver
NAFLD	Exclusion criteria	Viral hepatitis, drug-induced hepatitis, alcoholic fatty liver, autoimmune liver disease, liver degeneration
		Diagnosis of cirrhosis by ultrasound, CT, MRI, or liver biopsy pathology; neoplasm in liver or other organs
		With myocardial ischemia, hepatorenal syndrome, diabetes, infections, intestinal ischemia, cerebrovascular accident
		Albumin infusion within a month
Hepatitis	Inclusion criteria	Viral hepatitis over six months
		HBsAg and/or HBeAg positive
		Ultrasound, CT, MRI, or liver biopsy prompted no liver cirrhosis; AST, ALT < 40 U/L
Hepatitis	Exclusion criteria	Neoplasm in liver or other organs
		With myocardial ischemia, hepatorenal syndrome, diabetes, infections, intestinal ischemia, cerebrovascular accident
		Albumin infusion within a month
Cirrhosis	Inclusion criteria	Diagnosis of cirrhosis by ultrasound, CT, MRI, liver biopsy pathology, or operation
Cirrhosis	Exclusion criteria	Neoplasm in liver or other organs
		With myocardial ischemia, hepatorenal syndrome, diabetes, infections, intestinal ischemia, cerebrovascular accident
		Alcoholic, nonalcoholic, drug-induced, primary biliary cirrhosis, and unexplained hepatic cirrhosis albumin infusion within a month