Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis

Table 1

Downregulated proteins in GES-1 cells treated with deoxycholic acid (ratio < 0.2).

Number	Protein name		pI	Nominal mass	Protein function
1	Core histone macro-H2A.1	0.176	9.8	39617	Plays central roles in transcription regulation, DNA repair, DNA replication, and chromosomal stability
2	Cytospin-B	0.126	6.29	118585	Not clear
3	CREB-regulated transcription coactivator-3	0.133	6.35	66959	Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites
4	Bcl-2 antagonist of cell death	0.196	6.6	18392	Promotes cell death and successfully competes for the binding to Bcl-X (L), Bcl-2, and Bcl-W, thereby affecting the heterodimerization of these proteins with BAX
5	Vacuolar-sorting protein SNF8	0.139	6.2	28864	Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs
6	E3 ubiquitin-protein ligase UHRF1	0.169	7.66	89813	Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification

of the specific value of expression intensity of the protein in cells treated with or without deoxycholic acid.