Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL/6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway

<div>Exe enhances liver autophagy/mitophagy and inhibits the NLRP3 inflammasome. (a) Representative TEM images (20000x) from TEM showing characteristic autophagosomes (red arrow) and lipid droplets (yellow arrow) in livers. (b, c, d, e) Effects of Exe on LC3A/B, Beclin-1, Parkin, and BNIP3L in the livers as detected by Western blot. GAPDH served as the loading control. Representative Western blot images from each group were shown. 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Exe: exenatide; TEM: transmission electron microscope; GADPH: glyceraldehyde 3-phosphate dehydrogenase.</div>

Gastroenterology Research and Practice

fig3

Figure 3

Figure 3: Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL/6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway 

Figure 3 | Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL/6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway 