Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity

Figure 6

Mechanism of fucosterol action. In ConA-induced acute liver injury, fucosterol decreased P38 MAPK phosphorylation and contributed to the increased PPARγ transcriptional activity. Active PPARγ reduced the release of inflammatory factors that cause necrosis and apoptosis by inhibiting the NF-κB pathway. Additionally, Bcl-2, which is upregulated by PPARγ, can combine with Bax and Beclin-1 to reduce apoptosis and autophagy, respectively. Thus, fucosterol attenuates Concanavalin A-induced acute liver injury in mice via the P38 MAPK/PPARγ/NF-κB pathway.