Safety of Propofol versus Nonpropofol-Based Sedation in Children Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis

Table 3

Overall quality assessment, on basis of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.

Study	Starting level of evidence	Reasons for decreasing the level of evidence					Reasons to increase level of evidence (strong association, plausible confounding, and bias adjustment)	Final level of evidence
		Risk of bias	Inconsistency	Indirectness	Imprecision	Publication bias
Randomized trials—3	High	↓	↓	↔	↓	↔	↔	Very Low
Observational trials—4	Low	↓	↔	↔	↓	↔	↔	Very low