Precursors to Cholangiocarcinoma

Figure 1

Histology image of biliary cancer precursors. (a) Biliary intraepithelial neoplasia grade 1 (BilIN-1)—bile duct with tall columnar cells with mild nuclear abnormalities. (b) Biliary intraepithelial neoplasia grade 2 (BilIN-2)—bile duct with columnar cells with moderate nuclear abnormalities and focal pseudopapillary or micropapillary architecture of the epithelium. (c) Biliary intraepithelial neoplasia grade 3 (BilIN-3)—bile duct with columnar cells with severe nuclear abnormalities and pseudopapillary and cribriform architecture of the epithelial layer. Haematoxylin-eosin staining (courtesy of Dr. Jana Maluskova).

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