Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer

<div>CNN3 is important for the invasiveness of MKN-28 gastric cancer cells. (a) MKN-28 cells were transfected with control (siCon) or two different CNN3-specific siRNAs (siCNN3-1 and siCNN3-2) using siLentFect Lipid Reagent. Western blot analysis was performed against indicated antibodies. (b) Control siRNA- and CNN3 siRNA-transfected MKN-28 cells were seeded onto Matrigel matrix-coated upper chambers. The invasion activity of each cell was represented as % of control cells. 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(c) Control siRNA- and CNN3 siRNA-transfected MKN-28 cells were analyzed in wound-healing assays by visualizing wound closure via phase-contrast microscopy. (d) Effect of CNN3 depletion on the proliferation of MKN-28 cells.</div>

Gastroenterology Research and Practice

fig2

Figure 2

Figure 2: Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer 