Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia
Table 1
Demographic and clinical characteristics of the BA patients. Data were presented as frequencies (percentages), , or median (interquartile range [IQR]), as appropriate.
Variable
25-(OH)D sufficiency ()
25-(OH)D insufficiency ()
25-(OH)D deficiency ()
value
25-(OH)D
24.6 (22.8, 29.6)
12.4 (11.2, 14.5)
5.8 (3.6, 7.6)
<0.001
Age (days)
75 (57, 90)
63 (51, 80)
63 (53, 76)
0.508
Sex (male/female)
4/2
21/26
55/53
0.490
Weight (kg)
0.619
GGT (IU/l)
658.5 (160.8, 1023.5)
514.0 (349.0, 789.9)
474.0 (229.0, 847.0)
0.793
Albumin (g/l)
0.911
ALT (IU/l)
128.5 (80.0, 160.3)
109.0 (67.0, 191.0)
95.0 (73.8, 147.0)
0.442
AST (IU/l)
229.0 (104.3, 266.8)
172.0 (123.0, 241.0)
162.5 (113.3, 217.2)
0.595
TB (μmol/l)
157.0 (123.8, 183.5)
153.0 (122.0, 186.0)
155.5 (125.5, 181.3)
0.998
DB (μmol/l)
92.0 (78.5, 109.0)
97.2 (82.2, 127.0)
96.7 (82.0, 119.8)
0.645
ALP (IU/l)
479.5 (404.8, 571.0)
528.0 (443.0, 620.0)
606.0 (475.0, 756.5)
0.007
TCL (mmol/l)
5.0 (4.62, 6.25)
4.7 (4.0, 6.0)
5.0 (4.0, 5.4)
0.581
TBA (μmol/l)
127.2 (96.1, 256.0)
122.8 (95.0, 161.0)
123.6 (100.8, 153.4)
0.910
Phosphate (mmol/l)
0.980
Calcium (mmol/l)
0.408
Batts-Ludwig stage score
0.459
0, (%)
0 (0%)
0 (0%)
0 (0%)
1, (%)
0 (0%)
0 (0%)
0 (0%)
2, (%)
3 (50%)
21 (44.7%)
33 (30.6%)
3, (%)
2 (33%)
18 (38.3%)
55 (50.9%)
4, (%)
1 (17%)
8 (17.0%)
20 (18.5%)
Batts-Ludwig grade score
0.539
0, (%)
0 (0%)
0 (0%)
0 (0%)
1, (%)
0 (0%)
0 (0%)
3 (2.8%)
2, (%)
0 (0%)
9 (19.1%)
22 (20.4%)
3, (%)
6 (100%)
38 (80.9%)
83 (76.9%)
4, (%)
0 (0%)
0 (0%)
0 (0%)
PIIINP (ng/ml)
547.9 (306.2, 820.3)
371.2 (266.3, 508.2)
467.9 (318.0, 678.1)
0.041
CIV (ng/ml)
578.0 (425.9, 1027.7)
517.9 (376.2, 800.4)
565.3 (398.9, 916.9)
0.450
LN (ng/ml)
354.1 (154.5, 389.7)
352.1 (241.2, 449.6)
330.1 (245.4, 473.8)
0.777
HA (ng/ml)
212.4 (129.4, 459.5)
208.3 (160.5, 283.2)
218.1 (163.5, 328.1)
0.769
Season
0.050
Spring
1 (16.7%)
17 (36.2%)
48 (44.4%)
Summer
1 (16.7%)
17 (36.2%)
27 (25.0%)
Autumn
2 (33.3%)
1 (5.9%)
6 (5.6%)
Winter
2 (33.3%)
12 (25.5%)
27 (25.0%)
GGT: gamma-glutamyl transferase; ALT: alanine transaminase; AST: aspartate transaminase; TB: total bilirubin; DB: direct bilirubin; ALP: alkaline phosphatase; TCL: total cholesterol; TBA: total bile acids; PIIINP: N-terminal propeptide of type III procollagen; CIV: collagen type IV; LN: laminin; HA: hyaluronic acid.
