lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells

Figure 3

Mirt2 positively regulated IL-22 in HCnEpCs. Mirt2 expression vector or siRNA was transfected into HCnEpCs (treated with LPS as mentioned above). The expression level of Mirt2 was significantly altered in HCnEpCs with Mirt2 expression vector or siRNA transfection at 24 h after transfections comparing C and NC (a). Moreover, Mirt2 overexpression led to increased (b), while Mirt2 siRNA silencing led to decreased secretion of IL-22 from HCnEpCs in medium (c) ().

(a)

(b)

(c)