Preoperative Serum Platelet-Lymphocyte Ratio as a Prognostic Factor in Cholangiocarcinoma Patients after Radical Resection: A Retrospective Analysis of 119 Patients

Table 3

Kaplan–Meier method and Cox proportional hazard regression analysis of patients’ overall survival.

Variable	Univariable		Multivariable
	HR (95% CI)	value	HR (95% CI)	value
Gender (female/male)	2.273 (0.602-1.866)	0.793
Age (years) (<60/≥60)	1.978 (1.118-3.498)	0.015	1.317 (0.619-2.799)	0.474
ECOG (<2/=2)	2.983 (1.372-6.484)	0.003	1.112 (0.762-1.622)	0.582
Tumor location (iCC/pCC/dCC)	0.327 (0.513-0.996)	0.071
Lymphatic metastasis (no/yes)	1.888 (0.963-3.704)	0.056
Surgical margin (negative/positive)	3.066 (1.762-5.332)	<0.001	3.101 (1.678-5.729)	<0.001
Tumor size (mm) (≤40/>40)	1.339 (0.762-2.352)	0.300
Differentiation (poor/moderated/well)	0.250 (0.235-0.595)	<0.001	0.388 (0.239-0.630)	<0.001
Vascular invasion (no/yes)	1.009 (0.313-3.249)	0.988
Nerve invasion (no/yes)	0.820 (0.368-1.824)	0.619
PLR (<157.25/≥157.25)	2.493 (1.412-4.400)	0.001	2.160 (1.139-4.096)	0.018
CA199 (U/ml) (≤38/>38)	2.379 (1.536-4.897)	0.014	3.689 (1.706-7.978)	0.001
TBIL (μmol/L) (≤115/>115)	0.978 (0.564-1.696)	0.936

Abbreviations: PLR: platelet-lymphocyte ratio; ECOG: Eastern Cooperative Oncology Group; iCC: intrahepatic cholangiocarcinoma; pCC: perihilar cholangiocarcinoma; dCC: distal cholangiocarcinoma; CA199: carbohydrate antigen 19-9; TBIL: total bilirubin; HR: hazard ratio; CI: confidence; was considered significant.