A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database

Table 1

Demographics and clinicopathologic characteristics of patients with HCC (Abbreviations: Surg_site: surgery of primary site; AFP: the highest serum α-fetoprotein level prior to treatment; Scope_Reg-LN: scope of regional lymph node surgery; Marital_status: marital status at diagnosis; API: Asian or Pacific Islander; AI/AN: American Indian/Alaska Native).

Demographic character	Derivation cohort ()		Validation cohort ()
	No. of patients	%	No. of patients	%
Age					0.158
≤55	730	21.5	311	21.4
≤65	1186	34.9	467	32.1
≤75	1008	29.6	474	32.6
75+	476	14.0	204	14.0
Race					0.500
White	1947	57.3	831	57.1
Black	429	12.6	182	12.5
API	985	29.0	433	29.7
AI/AN	39	1.1	10	0.7
Sex
Male	2426	71.4	1034	71.0
Female	974	28.6	422	29.0
Grade					0.832
I	700	20.6	309	21.2
II	1855	54.6	802	55.1
III	773	22.7	314	21.6
IV	72	2.1	31	2.1
AJCC_8					0.803
IA	212	6.2	93	6.4
IB	1706	50.2	738	50.7
II	866	25.5	359	24.7
III(A/B)	215	6.3	80	5.5
IIIA	205	6.0	95	6.5
IIIB	196	5.8	91	6.3
Tumor_size					0.328
≤5 cm	1738	51.1	778	53.4
≤10 cm	1093	32.1	443	30.4
10+ cm	569	16.7	235	16.1
Surg_site					0.155
Wedge/segment	1936	56.9	849	58.3
Lobectomy	1170	34.4	505	34.7
Extend-lobectomy	294	8.6	102	7.0
Scope_Reg-LN		0.0			0.343
Yes	464	13.6	184	12.6
None/unknown	2936	86.4	1272	87.4
Radiation					0.757
Yes	70	2.1	32	2.2
No	3330	97.9	1424	97.8
Chemotherapy					0.479
Yes	436	12.8	176	12.1
No/unknown	2964	87.2	1280	87.9
AFP					0.318
Positive	1589	46.7	676	46.4
Negative	973	28.6	444	30.5
Unknown	838	24.6	336	23.1
Ishak_score					0.713
F0	668	19.6	301	20.7
F1	551	16.2	234	16.1
Unknown	2181	64.1	921	63.3
Marital_status					0.434
Married	2079	61.1	898	61.7
Never	535	15.7	248	17.0
Ever	661	19.4	258	17.7
Unknown	125	3.7	52	3.6